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Detailed forest plots for all secondary outcomes, subgroup analysis and ITCA 650 sensitivity analysis are included in Supplementary Appendix D, except pooled analysis of cardiovascular mortality where this is included in Fig

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70 The antioxidant properties of UA and its ability to inhibit oxidative stress may attenuate inflammatory damage to the nervous system and contribute to the maintenance of neuron number and function by inhibiting programmed apoptosis of neuronal cells, which protects against excessive neuronal cell damage

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